Poly(anhydride-esters) Comprised Exclusively of Naturally Occurring Antimicrobials and EDTA: Antioxidant and Antibacterial Activities

نویسندگان

  • Ashley L. Carbone-Howell
  • Nicholas D. Stebbins
  • Kathryn E. Uhrich
چکیده

Carvacrol, thymol, and eugenol are naturally occurring phenolic compounds known to possess antimicrobial activity against a range of bacteria, as well as antioxidant activity. Biodegradable poly(anhydride-esters) composed of an ethylenediaminetetraacetic acid (EDTA) backbone and antimicrobial pendant groups (i.e., carvacrol, thymol, or eugenol) were synthesized via solution polymerization. The resulting polymers were characterized to confirm their chemical composition and understand their thermal properties and molecular weight. In vitro release studies demonstrated that polymer hydrolytic degradation was complete after 16 days, resulting in the release of free antimicrobials and EDTA. Antioxidant and antibacterial assays determined that polymer release media exhibited bioactivity similar to that of free compound, demonstrating that polymer incorporation and subsequent release had no effect on activity. These polymers completely degrade into components that are biologically relevant and have the capability to promote preservation of consumer products in the food and personal care industries via antimicrobial and antioxidant pathways.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Fatty acid composition, antioxidant and antibacterial activities of Adonis wolgensis L. extract

Objectives: The objective of this study was to analyze the fatty acid content, antioxidant, and antibacterial activities of hydro-methanolic extract of Adonis wolgensis L. (A. wolgensis L.) growing wild in north of Iran. Materials and Methods: Oils of A. wolgensis L. was obtained by means of Soxhlet apparatus from leaves and stems. Methyl esters were derived from the oily mixtures by trans-este...

متن کامل

Antioxidant and Antimicrobial Activities of Naturally Occurring Flavonoids from M. heterophylla and the Safety Evaluation in Wistar Rats

Background: Maytenus heterophylla (M. heterophylla) is commonly used in African traditional medicine for the management of various ailments. The present study evaluated the antioxidant, antimicrobial and safety properties of the Flavonoid extract of M. heterophylla in Wister rats. Methods: The Flavonoid was subjected to antibacterial study via agar well diffusion method, and antioxidant stud...

متن کامل

A Review of Phytochemistry and Properties of Jujube (Ziziphus vulgaris L.)

Iran has a great wealth of various naturally occurring medicinal plants which have great potentialpharmacological activities. Ziziphus vulgaris known as Jujube is one of these plants. For a longtime Z. vulgaris has been used in alternative medicine as anti-hyperglycemic, anti-hyperlipidemiaand anti- hypertension. Z. vulgaris has recently been shown to have antibacterial, antioxidant,anti-hyperg...

متن کامل

Fatty acid composition, antioxidant and antibacterial activities of Adonis wolgensis L. extract

OBJECTIVES The objective of this study was to analyze the fatty acid content, antioxidant, and antibacterial activities of hydro-methanolic extract of Adonis wolgensis L. (A. wolgensis L.) growing wild in north of Iran. MATERIALS AND METHODS Oils of A. wolgensis L. was obtained by means of Soxhlet apparatus from leaves and stems. Methyl esters were derived from the oily mixtures by trans-este...

متن کامل

Controlled-release Antimicrobials for Preventing Biofilm Formation in Food and Medical Applications

OF THE THESIS CONTROLLED-RELEASE ANTIMICROBIALS FOR PREVENTING BIOFILM FORMATION IN FOOD AND MEDICAL APPLICATIONS By LINDA E. ROSENBERG Thesis Director: Dr. Michael Chikindas Bacterial biofilms generally are more resistant to stresses as compared to free planktonic cells. Therefore, the discovery of antimicrobial stress factors that have strong inhibitory effects on bacterial biofilm formation ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2014